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1

Correction by ketanserin of the platelet-mediated inhibition of peripheral collateral circulation in the cat: Measurement of blood flow with radioactive microspheres

Fred De Clerck, Wim Loots, Anton Jageneau, André Nevelsteen

Journal:

Drug Development Research

Year:

1986

Language:

english

File:

PDF, 583 KB

english, 1986

2

Synthetic inhibitors of human tissue kallikrein

D.Michael Evans, D.Michael Jones, Gary R Pitt, Doreen Ashworth, Fred De Clerck, Fons Verheyen, Michael Szelke

Journal:

Immunopharmacology

Year:

1996

Language:

english

File:

PDF, 139 KB

english, 1996

3

Determination of 6-keto-PGF1α, 2,3-dinor-6-keto-PGF1α, thromboxane B2, 2,3-dinor-thromboxane B2, PGE2, PGD2 and PGF2α in human urine by gas chromatography—negative ion chemical ionization mass spectrometry

Claudia Weber, Michael Höller, Johan Beetens, Fred De Clerck, Frank Tegtmeier

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

1991

Language:

english

File:

PDF, 505 KB

english, 1991

4

In vivo measurement of QT prolongation, dispersion and arrhythmogenesis: application to the preclinical cardiovascular safety pharmacology of a new chemical entity

Fred De Clerck, André Van de Water, Jan D'Aubioul, Hua Rong Lu, Koen Van Rossem, An Hermans, Karel Van Ammel

Journal:

Fundamental & Clinical Pharmacology

Year:

2002

Language:

english

File:

PDF, 220 KB

english, 2002

5

Species Plays an Important Role in Drug-Induced Prolongation of Action Potential Duration and Early Afterdepolarizations in Isolated Purkinje Fibers

HUA RONG LU, ROGER MARIËN, ANN SAELS, FRED DE CLERCK

Journal:

Journal of Cardiovascular Electrophysiology

Year:

2001

Language:

english

File:

PDF, 189 KB

english, 2001

6

Female Gender is a Risk Factor for Drug-Induced Long QT and Cardiac Arrhythmias in an In Vivo Rabbit Model

HUA RONG LU, PAUL REMEYSEN, KATRIEN SOMERS, AN SAELS, FRED DE CLERCK

Journal:

Journal of Cardiovascular Electrophysiology

Year:

2001

Language:

english

File:

PDF, 204 KB

english, 2001

7

Detection of Proarrhythmia in the Female Rabbit Heart: : Blinded Validation

LUC M. HONDEGHEM, HUA RONG LU, KOEN van ROSSEM, FRED De CLERCK

Journal:

Journal of Cardiovascular Electrophysiology

Year:

2003

Language:

english

File:

PDF, 328 KB

english, 2003

8

Blood platelets in human essential hypertension

Journal:

Inflammation Research

Year:

1986

Language:

english

File:

PDF, 1.42 MB

english, 1986

9

Inhibition of 5-hydroxytryptamine-induced and-amplified human platelet aggregation by ketanserin (R 41 468), a selective 5-HT2-receptor antagonist

Fred de Clerck, Jean-Louis David, Paul A. J. Janssen

Journal:

Inflammation Research

Year:

1982

Language:

english

File:

PDF, 686 KB

english, 1982

10

Effects of ketanserin, a selective 5-HT2serotonergic antagonist, on the secondary recruitment of human plateletsin vitro

Fred De Clerck, Benoit Xhonneux

Journal:

Inflammation Research

Year:

1986

Language:

english

File:

PDF, 907 KB

english, 1986

11

Biochemical mechanisms in 5-hydroxytryptamine-induced human platelet aggregation

Fred de Clerck, Benoit Xhonneux, Ronny van de Wiele

Journal:

Inflammation Research

Year:

1985

Language:

english

File:

PDF, 727 KB

english, 1985

12

Inhibition of 5-hydroxytryptamine-induced and-amplified human platelet aggregation by ketanserin (R 41 468), a selective 5-HT2-receptor antagonist

Fred de Clerck, Jean-Louis David, Paul A. J. Janssen

Journal:

Inflammation Research

Year:

1994

Language:

english

File:

PDF, 859 KB

english, 1994

13

Oxatomide protectsTrichinella spiralisinfected mice from lethal anaphylaxis

Fred De Clerck, Ludo Van Gorp, Oscar Vanparijs, Marcel Borger, Frans Awouters

Journal:

Inflammation Research

Year:

1978

Language:

english

File:

PDF, 290 KB

english, 1978

14

Gas chromatographic—mass spectrometric determination of 11-dehydrothromboxane B2 in human urine

Claudia Weber, Johan Beetens, Fred De Clerck, Frank Tegtmeier

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

1992

Language:

english

File:

PDF, 576 KB

english, 1992

15

Reduction in QT dispersion and ventricular arrhythmias by ischaemic preconditioning in anaesthetized, normotensive and spontaneously hypertensive rats

Hua-Rong Lu, Fing Yu, De-Za Dai, Paul Remeysen, Fred De Clerck

Journal:

Fundamental & Clinical Pharmacology

Year:

1999

Language:

english

File:

PDF, 862 KB

english, 1999

16

Ketanserin

Jan M. Van Nueten, Paul A. J. Janssen, Jan Symoens, Walter J. Janssens, Jozef Heykants, Fred De Clerck, Josée E. Leysen, Herman Vancauteren, Paul M. Vanhoutte

Journal:

Cardiovascular Therapeutics

Year:

1987

Language:

english

File:

PDF, 2.75 MB

english, 1987

17

Pharmacology of the Selective Phosphodiesterase III Inhibitor R 80122

Doris Wilhelm, Jürgen Schneider, Didier de Chaffoy de Courcelles, Raymond Xhonneux, Godelieve Vandeplassche, Fred de Clerck, Bob Wilffert, Thies Peters

Journal:

Cardiovascular Therapeutics

Year:

1993

Language:

english

File:

PDF, 1.37 MB

english, 1993

18

Specific modulation of calmodulin activity induces a dramatic production of superoxide by alveolar macrophages

Broeke, Robert Ten, Leusink-Muis, Thea, Hilberdink, Rogier, Van Ark, Ingrid, van den Worm, Edwin, Villain, Matteo, De Clerck, Fred, Blalock, J Edwin, Nijkamp, Frans P, Folkerts, Gert

Journal:

Laboratory Investigation

Year:

2003

Language:

english

File:

PDF, 243 KB

english, 2003

19

Effect of thromboxane A2 synthetase inhibition, singly and combined with thromboxane A2/prostaglandin endoperoxide receptor antagonism, on inositol phospholipid turnover and on 5-HT release by washed human platelets

Didier de Chaffoy de Courcelles, Fred De Clerck

Journal:

European Journal of Pharmacology: Molecular Pharmacology

Year:

1990

Language:

english

File:

PDF, 754 KB

english, 1990

20

The synergistic effect of 5-hydroxytryptamine and epinephrine on the human platelet is related to the activation of phospholipase C

Peter Roevens, Fred De Clerck, Didier de Chaffoy de Courcelles

Journal:

European Journal of Pharmacology: Molecular Pharmacology

Year:

1993

Language:

english

File:

PDF, 653 KB

english, 1993

21

Review of the predictive value of the Langendorff heart model (Screenit system) in assessing the proarrhythmic potential of drugs

Jean-Pierre Valentin, Peter Hoffmann, Fred De Clerck, Tim G Hammond, Luc Hondeghem

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2004

Language:

english

File:

PDF, 480 KB

english, 2004

22

Differential responsiveness of proximal and distal parts of isolated guinea pig trachea

Joris Kloek, Frans Nijkamp, Nanne Bloksma, Fred De Clerck, Gert Folkerts

Journal:

European Journal of Pharmacology

Year:

2002

Language:

english

File:

PDF, 147 KB

english, 2002

23

Drug-induced long QT in isolated rabbit Purkinje fibers: importance of action potential duration, triangulation and early afterdepolarizations

Hua Rong Lu, Eddy Vlaminckx, Karel Van Ammel, Fred De Clerck

Journal:

European Journal of Pharmacology

Year:

2002

Language:

english

File:

PDF, 194 KB

english, 2002

24

Ca2+ sensors modulate asthmatic symptoms in an allergic model for asthma

Robert Ten Broeke, Marcel C. Brandhorst, Thea Leusink-Muis, Matteo Villain, Fred De Clerck, J.Edwin Blalock, Frans P. Nijkamp, Gert Folkerts

Journal:

European Journal of Pharmacology

Year:

2003

Language:

english

File:

PDF, 226 KB

english, 2003

25

Ischemia/reperfusion-induced arrhythmias in anaesthetized rats: a role of Na+ and Ca2+ influx

Hua Rong Lu, Ping Yang, Paul Remeysen, Ann Saels, De Zai Dai, Fred De Clerck

Journal:

European Journal of Pharmacology

Year:

1999

Language:

english

File:

PDF, 116 KB

english, 1999

26

Platelet-mediated vascular contractions inhibition by flunarizine, a calcium-entry blocker

Fred De Clerck, Jan M. Van Nueten

Journal:

Biochemical Pharmacology

Year:

1983

Language:

english

File:

PDF, 623 KB

english, 1983

27

Demonstration of S2-receptor binding sites on cat blood platelets using [3H]ketanserin

Josee E. Leysen, Walter Gommeren, Fred De Clerck

Journal:

European Journal of Pharmacology

Year:

1983

Language:

english

File:

PDF, 409 KB

english, 1983

28

Differential effects of nebivolol on adrenoceptors in the heart and in resistance arterioles in the rat. Quantitative intravital microscopic analysis

Wim Loots, Fred De Clerck

Journal:

European Journal of Pharmacology

Year:

1990

Language:

english

File:

PDF, 586 KB

english, 1990

29

Oversensitivity to serotonin of the collateralized vascular bed in rat hindquarters: mechanisms of increased vasoconstriction

Alfons Verheyen, Freddie Lauwers, Eddy Vlaminckx, Luc Wouters, Fred de Clerck

Journal:

European Journal of Pharmacology

Year:

1991

Language:

english

File:

PDF, 708 KB

english, 1991

30

Inhibition of Na+/Ca2+ overload with R 56 865 protects against cardiac arrhythmias elicited by ouabain in vivo in guinea-pigs

Hua Rong Lu, Paul Remeysen, Fred De Clerck

Journal:

European Journal of Pharmacology

Year:

1993

Language:

english

File:

PDF, 442 KB

english, 1993

31

Selective vasoconstriction by alniditan in the carotid vascular bed of anaesthetized dogs

André Van de Water, Jan D'Aubioul, Willy Van Gerven, Karel Van Ammel, Fred De Clerck

Journal:

European Journal of Pharmacology

Year:

1996

Language:

english

File:

PDF, 969 KB

english, 1996

32

Thrombosis in canine coronary arteries: Inhibition by R 68070, a combined TXA2 synthetase inhibitor and TXA2PGH2 receptor antagonist

Godelieve Vandeplassche, Carlo Hermans, Andre Van de Water, Raymond Xhonneux, Marcel Borgers, Fred De Clerck

Journal:

Journal of Molecular and Cellular Cardiology

Year:

1990

Language:

english

File:

PDF, 114 KB

english, 1990

33

5-Hydroxytryptamine in thrombogenesis: mechanisms and in vivo relevance

Journal:

Journal of Molecular and Cellular Cardiology

Year:

1990

Language:

english

File:

PDF, 72 KB

english, 1990

34

Effect of R 80 122, a selective inhibitor of PDE type III, on the contractile function of stunning and failing hearts

Godelieve Vandeplassche, Carlo Hermans, Andre Van de Water, Raymond Xhonneux, Fred De Clerck

Journal:

Journal of Molecular and Cellular Cardiology

Year:

1992

Language:

english

File:

PDF, 112 KB

english, 1992

35

R 83 572, A Na+Ca2+-overload inhibitor, prevents ischemia- and reperfusion-induced ventricular arrhythmias: In vivo studies in the rats

Hua Rong Lu, Fred De Clerck

Journal:

Journal of Molecular and Cellular Cardiology

Year:

1992

Language:

english

File:

PDF, 87 KB

english, 1992

36

Cardioprotective effects of R 56 865 against cardiac arrhythmias induced by ouabain in anesthetized rabbits

Godelieve Vandeplassche, Leo Van Dael, Carlo Hermans, Fred De Clerck

Journal:

Journal of Molecular and Cellular Cardiology

Year:

1992

Language:

english

File:

PDF, 107 KB

english, 1992

37

In vitro effects of risperidone and 9-hydroxy-risperidone on human platelet function, plasma coagulation, and fibrinolysis

Fred De Clerck, Yves Somers, Erik Mannaert, Andrew Greenspan, Marielle Eerdekens

Journal:

Clinical Therapeutics

Year:

2004

Language:

english

File:

PDF, 1.08 MB

english, 2004

38

Virus-induced airway hyperresponsiveness in the guinea-pig: possible involvement of histamine and inflammatory cells

Gert Folkerts, Fred De Clerck, Ivonne Reijnart, Paul Span, Frans P. Nijkamp

Journal:

British Journal of Pharmacology

Year:

1993

Language:

english

File:

PDF, 1.96 MB

english, 1993

39

Combined thromboxane A2 synthetase inhibition and receptor blockade are effective in preventing spontaneous and epinephrine-induced canine coronary cyclic flow variations

Sheng-Kun Yao, Mark Rosolowsky, H.Vernon Anderson, Paolo Golino, Janice M. NcNatt, Fred de Clerck, L.Maximilian Buja, James T. Willerson

Journal:

Journal of the American College of Cardiology

Year:

1990

Language:

english

File:

PDF, 1.41 MB

english, 1990

40

Nocodazole, a new synthetic antimitotic agent, enhances the production of plasminogen activator by cells in culture

Fred De Clerck, Marc De Brabander

Journal:

Thrombosis Research

Year:

1977

Language:

english

File:

PDF, 92 KB

english, 1977

41

Direct evidence for the contractile capacity of endothelial cells

Fred De Clerck, Marc De Brabander, Hugo Neels, Vera Van de Velde

Journal:

Thrombosis Research

Year:

1981

Language:

english

File:

PDF, 838 KB

english, 1981

42

Platelet-mediated vascular contractions: Inhibition of the serotonergic component by ketanserin

Fred De Clerck, Jan M Van Nueten

Journal:

Thrombosis Research

Year:

1982

Language:

english

File:

PDF, 1.53 MB

english, 1982

43

Enhanced platelet turnover and prostaglandin production in spontaneously hypertensive rats

Fred De Clerck, Ludo Van Gorp, Benoit Xhonneux, Yves Somers, Luc Wouters

Journal:

Thrombosis Research

Year:

1982

Language:

english

File:

PDF, 481 KB

english, 1982

44

The involvement of 5-HT2-receptor sites in the activation of cat platelets

Fred De Clerck, Benoit Xhonneux, Josée Leysen, Paul A.J. Janssen

Journal:

Thrombosis Research

Year:

1984

Language:

english

File:

PDF, 1.07 MB

english, 1984

45

Dependence of the antagonism at human platelet 5-HT2 receptors by ketanserin on the reaction pH

Fred De Clerck, Benoit Xhonneux, Jan P. Tollenaere, Paul A.J. Janssen

Journal:

Thrombosis Research

Year:

1985

Language:

english

File:

PDF, 961 KB

english, 1985

46

Heparin knhances the synergism between platelet TXA2 synthase inhibitioh/receptor blockade (ridogrel) and tissue plasminogen activator in lysing canine coronary thrombi

Andre Van de Water, Raymond Xhonneux, Fred De Clerck, James T. Willerson

Journal:

Journal of the American College of Cardiology

Year:

1991

Language:

english

File:

PDF, 191 KB

english, 1991

47

Dual platelet thromboxane A2 synthase inhibition/endoperoxide receptor blockade (Ridogrel) and/or aspirin enhance thrombolysis with rt-PA in canine coronary arteries

Frans Van de Werf, Zaomin Wu, Tony M. Stassen, Fred F. De Clerck, Hilaire De Geest

Journal:

Journal of the American College of Cardiology

Year:

1991

Language:

english

File:

PDF, 253 KB

english, 1991

48

Combined thromboxane A2 synthase inhibition and prostaglandin endoperoxide receptor antagonism limits myocardial infarct size after mechanical coronary occlusion and reperfusion at doses enhancing coronary thrombolysis by streptokinase

Godelieve Vandeplassche, Carlo Hermans, Yves Somers, Frans Van de Werf, Fred de Clerck

Journal:

Journal of the American College of Cardiology

Year:

1993

Language:

english

File:

PDF, 982 KB

english, 1993

49

Overexpression of endothelial nitric oxide synthase suppresses features of allergic asthma in mice

Robert Ten Broeke, Rini De Crom, Rien Van Haperen, Vivienne Verweij, Thea Leusink-Muis, Ingrid Van Ark, Fred De Clerck, Frans P Nijkamp, Gert Folkerts

Journal:

Respiratory Research

Year:

2006

Language:

english

File:

PDF, 1.10 MB

english, 2006

50

Preclinical Cardiovascular Safety Evaluations of Biologics

Hondeghem, Luc, Clerck, Fred

Journal:

Year:

2012

Language:

english

File:

PDF, 148 KB

english, 2012